The mission of Technometrics is to contribute to the development and use of statistical methods in the physical, chemical, and engineering sciences. Its content features papers that describe new statistical techniques, illustrate innovative application of known statistical methods, or review methods, issues, or philosophy in a particular area of statistics or science, when such papers are consistent with the journal's mission. Application of proposed methodology is justified, usually by means of an actual problem in the physical, chemical, or engineering sciences.

Papers in the journal reflect modern practice. This includes an emphasis on new statistical approaches to screening, modeling, pattern characterization, and change detection that take advantage of massive computing capabilities. Papers also reflect shifts in attitudes about data analysis (e.g., less formal hypothesis testing, more fitted models via graphical analysis), and in how important application areas are managed (e.g., quality assurance through robust design rather than detailed inspection).