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Nosocomial Methicillin‐Resistant and Methicillin‐Susceptible Staphylococcus aureus Primary Bacteremia: At What Costs?
Murray A. Abramson , MD and Daniel J. Sexton , MD
Infection Control and Hospital Epidemiology
Vol. 20, No. 6 (June 1999), pp. 408-411
Published by: Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America
Stable URL: http://www.jstor.org/stable/10.1086/501641
Page Count: 4
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OBJECTIVE. To determine the attributable hospital stay and costs for nosocomial methicillin‐sensitive Staphylococcus aureus (MSSA) and methicillin‐resistant S aureus (MRSA) primary bloodstream infections (BSIs). DESIGN. Pairwise‐matched (1:1) nested case‐control study. SETTING. University‐based tertiary‐care medical center. PATIENTS. Patients admitted between December 1993 and March 1995 were eligible. Cases were defined as patients with a primary nosocomial S aureus BSI; controls were selected according to a priori matching criteria. MEASUREMENTS. Length of hospital stay and total and variable direct costs of hospitalization. RESULTS. The median hospital stay attributable to primary nosocomial MSSA BSI was 4 days, compared with 12 days for MRSA (P=.023). Attributable median total cost for MSSA primary nosocomial BSIs was $9,661 versus $27,083 for MRSA nosocomial infections (P=.043). CONCLUSION. Nosocomial primary BSI due to S aureus significantly prolongs the hospital stay. Primary nosocomial BSIs due to MRSA result in an approximate threefold increase in direct cost, compared with those due to MSSA.
© 1999 by The Society for Healthcare Epidemiology of America. All rights reserved.