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Effect of Zidovudine Postexposure Prophylaxis on the Development of HIV‐Specific Cytotoxic T‐Lymphocyte Responses in HIV‐Exposed Healthcare Workers

Ronnie D’Amico , DO, Ligia A. Pinto , MD, Peter Meyer , PhD, Alan L. Landay , PhD, Alan A. Harris , MD, Mario Clerici , MD, Jay A. Berzofsky , MD, PhD, Gene M. Shearer , PhD and Harold A. Kessler , MD
Infection Control and Hospital Epidemiology
Vol. 20, No. 6 (June 1999), pp. 428-430
DOI: 10.1086/501646
Stable URL: http://www.jstor.org/stable/10.1086/501646
Page Count: 3
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Effect of Zidovudine Postexposure Prophylaxis on the Development of HIV‐Specific Cytotoxic T‐Lymphocyte Responses in HIV‐Exposed Healthcare Workers
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Abstract

ABSTRACT We evaluated the effects of zidovudine postexposure prophylaxis (PEP) on the development of human immunodeficiency virus (HIV) envelope‐specific cytotoxic T‐lymphocyte responses in 20 healthcare workers with occupational exposures to HIV. Seven healthcare workers were treated with zidovudine PEP. Only 1 of 7 treated, versus 6 of 13 not treated, developed an HIV envelopespecific cytotoxic T‐lymphocyte response. These data suggest that zidovudine abrogated HIV‐specific cytotoxic T‐lymphocyte responses. HIV‐specific cytotoxic T‐lymphocyte responses may be useful as a surrogate marker of HIV replication in the evaluation of new regimens for PEP of occupational HIV exposures.

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