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Can Whipple’s Disease Be Transmitted by Gastroscopes?
Bernard La Scola , MD, PhD, Jean‐Marc Rolain , PharmD, PhD, Max Maurin , MD, PhD and Didier Raoult , MD, PhD
Infection Control and Hospital Epidemiology
Vol. 24, No. 3 (March 2003), pp. 191-194
Published by: Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America
Stable URL: http://www.jstor.org/stable/10.1086/502188
Page Count: 5
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OBJECTIVE. To determine whether disinfection protocols currently used for gastroscopes are effective against cultures of Tropheryma whipplei. DESIGN. The bactericidal activity of 2% glutaraldehyde and two peracetic acids on the Twist‐Marseille strain of T. whipplei grown in cell monolayers was determined. PATIENTS. Two patients who were diagnosed as having Whipple’s disease 3 years after they had had intestinal biopsies. RESULTS. The disinfectants reduced bacteria by approximately 2 log10 to 3 log10 after 5 to 60 minutes of contact. CONCLUSION. The bactericidal activity of a disinfectant is usually considered significant if it causes a 5 log10 or greater reduction in viable bacterial titers. Disinfecting gastroscopes with 2% glutaraldehyde or peracetic acids for 20 minutes may be insufficient to prevent transmission of T. whipplei on the instruments or stop false‐positive results on polymerase chain reaction.
© 2003 by The Society for Healthcare Epidemiology of America. All rights reserved.