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Coadministration of Oral Levofloxacin With Agents That Impair Absorption: Impact on Antibiotic Resistance

Keira A. Cohen , BS, Ebbing Lautenbach , MD, MPD, MSCE, Mark G. Weiner , MD, Marie Synnestvedt , MSED and Leanne B. Gasink , MD, MSCE
Infection Control and Hospital Epidemiology
Vol. 29, No. 10 (October 2008), pp. 975-977
DOI: 10.1086/590666
Stable URL: http://www.jstor.org/stable/10.1086/590666
Page Count: 3
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Coadministration of Oral Levofloxacin With Agents That Impair Absorption: Impact on Antibiotic Resistance
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Abstract

Coadministration of oral divalent or trivalent cation‐containing compounds with oral fluoroquinolones may impair fluoroquinolone absorption. Among 3,134 patients who received a course of oral levofloxacin, coadministration was significantly associated with subsequent identification of a levofloxacin‐resistant isolate. Strategies to curb the emergence of fluoroquinolone resistance should include avoiding the coadministration of divalent or trivalent cation‐containing compounds and fluoroquinolone.

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