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Evaluation of the Effect of Treatment of Latent Tuberculosis Infection on QuantiFERON‐TB Gold Assay Results

Nira R. Pollock , MD, PhD, Suely S. Kashino , PhD, Danielle R. Napolitano , PhD, Alex Sloutsky , PhD, Swati Joshi , PhD, Jasmine Guillet , MPH, Michael Wong , MD, Edward Nardell , MD and Antonio Campos‐Neto , MD, PhD
Infection Control and Hospital Epidemiology
Vol. 30, No. 4 (April 2009), pp. 392-395
DOI: 10.1086/596606
Stable URL: http://www.jstor.org/stable/10.1086/596606
Page Count: 4
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Evaluation of the Effect of Treatment of Latent Tuberculosis Infection on QuantiFERON‐TB Gold Assay Results
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Abstract

To evaluate the utility of the QuantiFERON‐TB Gold assay for monitoring latent tuberculosis treatment efficacy, the assay was performed serially for healthcare workers receiving isoniazid therapy. After 9 months of isoniazid therapy, all of these healthcare workers remained QuantiFERON‐TB Gold positive, and cellular proliferation assays revealed persistently strong purified protein derivative responses. These results do not support the use of the QuantiFERON‐TB Gold assay to monitor therapy.

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