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Prospective Comparison of Tuberculin Skin Test and QuantiFERON‐TB Gold In‐Tube Assay for the Detection of Latent Tuberculosis Infection among Healthcare Workers in a Low‐Incidence Setting

Kristin J. Cummings , MD, MPH, Tamara S. Smith , MD, Elizabeth S. Shogren , PhD, Rashida Khakoo , MD, Sharmilarani Nanda , MD, Lana Bunner , RN, BSN, Ann Smithmyer , RN, MSN, FNP‐BC, Darlene Soccorsi , RN, MSN, FNP‐BC, Michael L. Kashon , PhD, Gerald H. Mazurek , MD, Lloyd N. Friedman , MD and David N. Weissman , MD
Infection Control and Hospital Epidemiology
Vol. 30, No. 11 (November 2009), pp. 1123-1126
DOI: 10.1086/644754
Stable URL: http://www.jstor.org/stable/10.1086/644754
Page Count: 4
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Prospective Comparison of Tuberculin Skin Test and QuantiFERON‐TB Gold In‐Tube Assay for the Detection of Latent Tuberculosis Infection among Healthcare Workers in a Low‐Incidence Setting
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Abstract

We compared the results of the tuberculin skin test with the results of the QuantiFERON‐TB Gold In‐Tube (QFT‐GIT) assay among 182 low‐risk healthcare workers. Overall agreement and specificity were high, but the tests did not agree on positive results. Only 2 of 5 positive QFT‐GIT assay results could be confirmed with repeat analyses. Indeterminate results were associated with potential immunosuppression.

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