You are not currently logged in.

Access JSTOR through your library or other institution:


Log in through your institution.

Journal Article

Outbreak of Carbapenem‐Resistant Klebsiella pneumoniae in Puerto Rico Associated with a Novel Carbapenemase Variant

Christopher J. Gregory , MD, MPH, Eloisa Llata , MD, Nicholas Stine , MD, Carolyn Gould , MD, Luis Manuel Santiago , MS, Guillermo J. Vazquez , MD, Iraida E. Robledo , PhD, Arjun Srinivasan , MD, Richard V. Goering , PhD and Kay M. Tomashek , MD, MPH
Infection Control and Hospital Epidemiology
Vol. 31, No. 5 (May 2010), pp. 476-484
DOI: 10.1086/651670
Stable URL:
Page Count: 9
Were these topics helpful?
See something inaccurate? Let us know!

Select the topics that are inaccurate.

  • Subscribe ($19.50)
  • Add to My Lists
  • Cite this Item
Outbreak of Carbapenem‐Resistant Klebsiella pneumoniae in Puerto Rico Associated with a Novel Carbapenemase Variant
Preview not available


Background.  Carbapenem‐resistant Klebsiella pneumoniae (CRKP) is resistant to almost all antimicrobial agents, and CRKP infections are associated with substantial morbidity and mortality. Objective.  To describe an outbreak of CRKP in Puerto Rico, determine risk factors for CRKP acquisition, and detail the successful measures taken to control the outbreak. Design.  Two case‐control studies. Setting.  A 328‐bed tertiary care teaching hospital. Patients.  Twenty‐six CRKP case patients identified during the outbreak period of February through September 2008, 26 randomly selected uninfected control patients, and 26 randomly selected control patients with carbapenem‐susceptible K. pneumoniae (CSKP) hospitalized during the same period. Methods.  We performed active case finding, including retrospective review of the hospital’s microbiology database and prospective perirectal surveillance culture sampling in high‐risk units. Case patients were compared with each control group while controlling for time at risk. We sequenced the blaKPC gene with polymerase chain reaction for 7 outbreak isolates and subtyped these isolates with pulsed‐field gel electrophoresis. Results. In matched, multivariable analysis, the presence of wounds (hazard ratio, 19.0 [95% confidence interval {CI}, 2.5–142.0]) was associated with CRKP compared with no K. pneumoniae. Transfer between units (adjusted odds ratio [OR], 7.5 [95% CI, 1.8–31.1]), surgery (adjusted OR, 4.0 [95% CI, 1.0–15.7]), and wounds (adjusted OR, 4.9 [95% CI, 1.1–21.8]) were independent risk factors for CRKP compared to CSKP. A novel K. pneumoniae carbapenemase variant (KPC‐8) was present in 5 isolates. Implementation of active surveillance for CRKP colonization and cohorting of CRKP patients rapidly controlled the outbreak. Conclusions.  Enhanced surveillance for CRKP colonization and intensified infection control measures that include limiting the physical distribution of patients can reduce CRKP transmission during an outbreak.

Page Thumbnails