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An Outbreak of Burkholderia cepacia Complex Associated with Intrinsically Contaminated Nasal Spray
Susan A. Dolan RN MS CIC, Elaine Dowell MT SM(ASCP), John J. LiPuma MD, Sondra Valdez RN BSN, Kenny Chan >MD and John F. James PhD MPH D(ABMM)
Infection Control and Hospital Epidemiology
Vol. 32, No. 8 (August 2011), pp. 804-810
Published by: Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America
Stable URL: http://www.jstor.org/stable/10.1086/660876
Page Count: 7
You can always find the topics here!Topics: Nasal sprays, Sinuses, Broths, Blood, Infections, Bottles, Benzalkonium compounds, Surgical procedures, Surgical specialties, Manufacturing processes
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Objective. To determine the source of Burkholderia cepacia complex associated with a hospital outbreak and describe the measures taken to identify and confirm the source.Setting. A 250-bed, tertiary care pediatric hospital in Denver, Colorado.Methods. An epidemiologic investigation was used to identify possible causes for an apparent outbreak of B. cepacia complex in pediatric patients who had new positive cultures with this organism from December 2003 to February 2004. Chart review, microbiology reports, surgical records, site visits, literature review, staff interviews, and cultures of common products and equipment were performed to determine a source of contamination. Random amplified polymorphic DNA and pulsed-field gel electrophoresis typing, performed by 2 independent laboratories, were used for molecular typing of patient and source isolates.Results. Five pediatric patients had new positive B. cepacia complex cultures from either the sinus or the respiratory tract, and all 5 patients had prior exposure to 0.05% oxymetazoline hydrochloride Major Twice-A-Day 12-hour nasal spray (Proforma, Miami, FL). Four of the 5 patients had isolates that were identical to the B. cepacia complex isolates recovered from the unopened Twice-A-Day 12-hour nasal spray.Conclusions. Intrinsic contamination of Major Twice-A-Day 12-hour nasal spray with B. cepacia complex resulted in nosocomial transmission to 4 patients at our facility and resulted in a voluntary product recall by the manufacturer. B. cepacia complex species are common contaminants of an increasing variety of nonsterile medical products. Enhanced culture techniques may be useful in evaluating possible product contamination, suggesting additional measures that should be considered to assure the safety of products that may be used in high-risk patients.
© 2011 by The Society for Healthcare Epidemiology of America. All rights reserved.