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Sequence Matters: Genomic Research and the Gene Concept
Philosophy of Science
Vol. 78, No. 5 (December 2011), pp. 752-762
Stable URL: http://www.jstor.org/stable/10.1086/662565
Page Count: 11
You can always find the topics here!Topics: Genomes, Genomics, Open reading frames, Genes, Nucleotide sequences, Amino acids, DNA, RNA, Codons, Nucleotides
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Analysis of two key ways of characterizing genes—as causes of phenotypic effects and as genomic DNA sequences—has yielded widespread pessimism that they can be united in a coherent gene concept. This raises important questions about the epistemology of genomic research: If analysis of a genome sequence cannot yield information about genes defined both in terms of their products and their DNA sequence, then what could we learn from it? I investigate basic tools of genomic analysis, argue that they do not reflect the application of either gene concept, and clarify how we learn from genomic research.
Copyright 2011 by the Philosophy of Science Association. All rights reserved.