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A Multicenter Study of Clostridium difficile Infection–Related Colectomy, 2000–2006

Amelia M. Kasper MD, Humaa A. Nyazee MPH, Deborah S. Yokoe MD, Jeanmarie Mayer MD, Julie E. Mangino MD, Yosef M. Khan MD, Bala Hota MD, Victoria J. Fraser MD, Erik R. Dubberke MD and Centers for Disease Control and Prevention Epicenters Program
Infection Control and Hospital Epidemiology
Vol. 33, No. 5 (May 2012), pp. 470-476
DOI: 10.1086/665318
Stable URL: http://www.jstor.org/stable/10.1086/665318
Page Count: 7
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A Multicenter Study of <em>Clostridium difficile</em> Infection–Related Colectomy, 2000–2006


Objective. To assess Clostridium difficile infection (CDI)–related colectomy rates by CDI surveillance definitions and over time at multiple healthcare facilities.Setting. Five university-affiliated acute care hospitals in the United States.Design and methods. Cases of CDI and patients who underwent colectomy from July 2000 through June 2006 were identified from 5 US tertiary care centers. Monthly CDI-related colectomy rates were calculated as the number of CDI-related colectomies per 1,000 CDI cases, and cases were categorized according to recommended surveillance definitions. Logistic regression was performed to evaluate risk factors for CDI-related colectomy.Results. In total, 8,569 cases of CDI were identified, and 75 patients underwent CDI-related colectomy. The overall colectomy rate was 8.7 per 1,000 CDI cases. The CDI-related colectomy rate ranged from 0 to 23 per 1,000 CDI episodes across hospitals. The colectomy rate for healthcare-facility-onset CDI was 4.3 per 1,000 CDI cases, and that for community-onset CDI was 16.5 per 1,000 CDI cases (). There were significantly more CDI-related colectomies at hospitals B and C ().Conclusions. The overall CDI-related colectomy rate was low, and there was no significant change in the CDI-related colectomy rate over time. Onset of disease outside the study hospital was an independent risk factor for colectomy.

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