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Epidemiology of Vancomycin-Resistant Enterococci with Reduced Susceptibility to Daptomycin

Theresa Judge PharmD, Jason M. Pogue PharmD, Dror Marchaim MD, Kevin Ho BA, Srinivasa Kamatam MBBS, Shakila Parveen MBBS, Namita Tiwari MBBS, Priyanka Nanjireddy MBBS, Suchitha Bheemreddy MBBS, Caitlin Biedron MS, Sagar Mallikethi Lepakshi Reddy MBBS, Vijaykumar Khammam, Indu K. Chalana MBBS, Rajachendra Shekher Tumma MBBS, Vicki Collins MD MPH, Adnan Yousuf MD, Paul R. Lephart PhD, Emily T. Martin PhD, Michael J. Rybak PharmD MPH, Keith S. Kaye MD MPH and Kayoko Hayakawa MD PhD
Infection Control and Hospital Epidemiology
Vol. 33, No. 12 (December 2012), pp. 1250-1254
DOI: 10.1086/668438
Stable URL: http://www.jstor.org/stable/10.1086/668438
Page Count: 5
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Epidemiology of Vancomycin-Resistant Enterococci with Reduced Susceptibility to Daptomycin
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Abstract

A retrospective case–case control study was conducted, including 60 cases with daptomycin-nonsusceptible vancomycin-resistant enterococci (DNS-VRE) matched to cases with daptomycin-susceptible VRE and to uninfected controls (1∶1∶3 ratio). Immunosuppression, presence of comorbid conditions, and prior exposure to antimicrobials were independent predictors of DNS-VRE, although prior daptomycin exposure occurred rarely. In summary, a case–case control study identified independent risk factors for the isolation of DNS-VRE: immunosuppression, multiple comorbid conditions, and prior exposures to cephalosporines and metronidazole.

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