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Patient- and Device-Specific Risk Factors for Peripherally Inserted Central Venous Catheter–Related Bloodstream Infections
Makhawadee Pongruangporn MD, M. Cristina Ajenjo MD, Anthony J. Russo MPH, Kathleen M. McMullen MPH, Catherine Robinson BA, Robert C. Williams BS MBA and David K. Warren MD MPH
Infection Control and Hospital Epidemiology
Vol. 34, No. 2 (February 2013), pp. 184-189
Published by: Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America
Stable URL: http://www.jstor.org/stable/10.1086/669083
Page Count: 6
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Objective. To determine the patient- and device-specific risk factors for hospital-acquired peripherally inserted central venous catheter–related bloodstream infections (PICC BSIs) in adult patients.Design. Nested case-control study.Setting. Barnes-Jewish Hospital, a 1,252-bed tertiary care teaching hospital.Patients. Adult patients with PICCs placed from January 1, 2006, through July 31, 2008.Methods. PICC BSI cases were identified using the National Healthcare Safety Network definition. Uninfected control patients with PICCs in place were randomly selected at a 3∶1 ratio. Patient- and device-related variables were examined using multivariate analysis.Results. The overall PICC BSI rate was 3.13 per 1,000 catheter-days. Independent risk factors for PICC BSIs included congestive heart failure (odds ratio [OR], 2.0 [95% confidence interval (CI), 1.26–3.17]; ), intra-abdominal perforation (OR, 5.66 [95% CI, 1.76–18.19]; ), Clostidium difficile infection (OR, 2.25 [95% CI, 1.17–4.33]; ), recent chemotherapy (OR, 3.36 [95% CI, 1.15–9.78]; ), presence of tracheostomy (OR, 5.88 [95% CI, 2.99–11.55]; ), and type of catheter (OR for double lumen, 1.89 [95% CI, 1.15–3.10]; ; OR for triple lumen, 2.87 [95% CI, 1.39–5.92]; ). Underlying chronic obstructive pulmonary disease (OR, 0.48 [95% CI, 0.29–0.78]; ) and admission to surgical (OR, 0.43 [95% CI, 0.24–0.79]; ) or oncology and orthopedic (OR, 0.35 [95% CI, 0.13–0.99]; ) services were less likely to be associated with having a PICC BSI.Conclusions. We identified several novel factors related to PICC BSIs. These factors may inform preventive measures.
© 2012 by The Society for Healthcare Epidemiology of America. All rights reserved.