Front Matter
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Extrasolar systems shed light on our own
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Golden microbial art
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Connectome
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Profile of John Gurdon and Shinya Yamanaka, 2012 Nobel Laureates in Medicine or Physiology
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Sensing conformational changes in metabotropic glutamate receptors
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A "slow" protein folds quickly in the end
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Lamprey immunity is far from primitive
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Combined roles of ethylene and endogenous peptides in regulating plant immunity and growth
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PNAS PLUS: Significance Statements
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Identification of a previously undescribed divergent virus from the Flaviviridae family in an outbreak of equine serum hepatitis
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Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors
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Probing the relative orientation of molecules bound to DNA through controlled interference using second-harmonic generation
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Single-cell label-free photoacoustic flowoxigraphy in vivo
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Ramanujan's mock theta functions
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Dense colloidal fluids form denser amorphous sediments
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Spectroscopic evidence for Fermi liquid-like energy and temperature dependence of the relaxation rate in the pseudogap phase of the cuprates
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Anticipating land surface change
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Transformation of social networks in the late pre-Hispanic US Southwest
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Biased assimilation, homophily, and the dynamics of polarization
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Social isolation, loneliness, and all-cause mortality in older men and women
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Private traits and attributes are predictable from digital records of human behavior
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Potential shortfall of pyramided transgenic cotton for insect resistance management
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Key role for a glutathione transferase in multiple-herbicide resistance in grass weeds
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Early cercopithecid monkeys from the Tugen Hills, Kenya
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Aye-aye population genomic analyses highlight an important center of endemism in northern Madagascar
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Stable isotope evidence of meat eating and hunting specialization in adult male chimpanzees
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Family of pH (low) insertion peptides for tumor targeting
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Exploiting microbial hyperthermophilicity to produce an industrial chemical, using hydrogen and carbon dioxide
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In vitro and in vivo delivery of genes and proteins using the bacteriophage T4 DNA packaging machine
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Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis
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Ring cycle for dilating and constricting the nuclear pore
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Critical role of parathyroid hormone (PTH) receptor-1 phosphorylation in regulating acute responses to PTH
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Evolutionary mix-and-match with MFS transporters
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Characterization of platelet aminophospholipid externalization reveals fatty acids as molecular determinants that regulate coagulation
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M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation
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Dimers of mitochondrial ATP synthase form the permeability transition pore
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Substrate selectivity in arginine-dependent acid resistance in enteric bacteria
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Substrate selectivity in glutamate-dependent acid resistance in enteric bacteria
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EJC core component MLN51 interacts with elF3 and activates translation
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Strong subunit coordination drives a powerful viral DNA packaging motor
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Atomic-level description of ubiquitin folding
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Glutamate receptor desensitization is mediated by changes in quaternary structure of the ligand binding domain
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Spatial partitioning improves the reliability of biochemical signaling
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Toward an atomistic description of the urea-denatured state of proteins
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Mechanism of voltage-sensitive fluorescence in a microbial rhodopsin
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Responses of Mn²⁺ speciation in Deinococcus radiodurans and Escherichia coli to γ-radiation by advanced paramagnetic resonance methods
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Cell-to-cell propagation of infectious cytosolic protein aggregates
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Paradoxical activation and RAF inhibitor resistance of BRAF protein kinase fusions characterizing pediatric astrocytomas
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Phosphatidylinositol 5-phosphate 4-kinase (PIP4K) regulates TOR signaling and cell growth during Drosophila development
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Pim-1 preserves mitochondrial morphology by inhibiting dynamin-related protein 1 translocation
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Hsp70 nucleotide exchange factor Fes1 is essential for ubiquitin-dependent degradation of misfolded cytosolic proteins
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The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway
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CCDC41 is required for ciliary vesicle docking to the mother centriole
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Candidate tumor suppressor BTG3 maintains genomic stability by promoting Lys63-linked ubiquitination and activation of the checkpoint kinase CHK1
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Decreased water flowing from a forest amended with calcium silicate
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Structure of the rare archaeal biosphere and seasonal dynamics of active ecotypes in surface coastal waters
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Turnover of microbial lipids in the deep biosphere and growth of benthic archaeal populations
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Mechanical basis of morphogenesis and convergent evolution of spiny seashells
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TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
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Regional control of histone H3 lysine 27 methylation in Neurospora
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De novo centromere formation on a chromosome fragment in maize
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The human placenta methylome
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Organization of lamprey variable lymphocyte receptor C locus and repertoire development
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Structural basis for HIV-1 gp120 recognition by a germ-line version of a broadly neutralizing antibody
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A T-cell response to a liver-stage Plasmodium antigen is not boosted by repeated sporozoite immunizations
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Targeting complement component 5a promotes vascular integrity and limits airway remodeling
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Eosinophil adoptive transfer system to directly evaluate pulmonary eosinophil trafficking in vivo
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An initial and rapid step of lytic granule secretion precedes microtubule organizing center polarization at the cytotoxic T lymphocyte/target cell synapse
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Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF—induced neutrophil recruitment
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Parkinson-susceptibility gene DJ-1/PARK7 protects the murine heart from oxidative damage in vivo
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Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia
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Transient treatment with epigenetic modifiers yields stable neuroblastoma stem cells resembling aggressive large-cell neuroblastomas
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Hunk negatively regulates c-myc to promote Akt-mediated cell survival and mammary tumorigenesis induced by loss of Pten
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Genomic and functional characterizations of phosphodiesterase subtype 4D in human cancers
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Ligand-functionalized nanoparticles target endothelial cells in retinal capillaries after systemic application
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Development and validation of a 32-gene prognostic index for prostate cancer progression
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Targeting chronic lymphocytic leukemia cells with a humanized monoclonal antibody specific for CD44
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Insight into the assembly mechanism in the supramolecular rings of the sodium-driven Vibrio flagellar motor from the structure of FlgT
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Normalization is a general neural mechanism for context-dependent decision making
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Neural mechanisms underlying heterogeneity in the presentation of anxious temperament
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Single dopaminergic neurons that modulate aggression in Drosophila
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TRPV4 Channels stimulate Ca²⁺-induced Ca²⁺ release in astrocytic endfeet and amplify neurovascular coupling responses
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Fly cryptochrome and the visual system
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Structural foundations of resting-state and task-based functional connectivity in the human brain
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An oculomotor continuum from exploration to fixation
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Evidence that Igf2 down-regulation in postnatal tissues and up-regulation in malignancies is driven by transcription factor E2f3
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Transgenic overexpression of ribonucleotide reductase improves cardiac performance
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Hunger-promoting hypothalamic neurons modulate effector and regulatory T-cell responses
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Sclerostin alters serum vitamin D metabolite and fibroblast growth factor 23 concentrations and the urinary excretion of calcium
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BIK1 interacts with PEPRs to mediate ethylene-induced immunity
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Layered pattern receptor signaling via ethylene and endogenous elicitor peptides during Arabidopsis immunity to bacterial infection
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Predicting free choices for abstract intentions
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Neuroprediction of future rearrest
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Achieving the triple bottom line in the face of inherent trade-offs among social equity, economic return, and conservation
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Universal distribution of component frequencies in biological and technological systems
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Correction: A mathematical model of fluid and gas flow in nanoporous media
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Correction: Sequence-based prediction of single nucleosome positioning and genome-wide nucleosome occupancy
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Correction: Improving spinning disk confocal microscopy by preventing pinhole cross-talk for intravital imaging
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Correction: The Role of Nanostructure in the Wetting Behavior of Mixed-Monolayer-Protected Metal Nanoparticles
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Back Matter
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