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Journal Article

Neurogenic responses in rat and porcine large pulmonary arteries

Daniel J. Duggan, Detlef Bieger and Reza Tabrizchi
Pulmonary Circulation
Vol. 1, No. 3 (July 2011), pp. 419-424
DOI: 10.4103/2045-8932.87311
Stable URL:
Page Count: 6
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AbstractPharmacological differences between neurogenic sympathetic responses in rat and pig isolated pulmonary arteries were examined in strip preparations. Electrical field stimulation in the range of 0.6 to 40 Hz resulted in frequency-dependent contractions in terms of amplitude and rate of rise. Responses in the rat declined sharply from pulmonary trunk to main artery; in contrast, in the pig they continued into the third-order vessels. Contractions were inhibited in the presence of tetrodotoxin, prazosin or WB-4101 and hence neurogenic in origin. Cocaine enhanced field stimulated contractions in both rat and porcine tissues; however, the effect in the former was of significantly greater magnitude in terms of either area under the mechanogram or height of contraction. In addition, the rate of rise, time to peak and duration of peak were all increased in the rat but less so or not in the pig. Field stimulated contractions were virtually abolished by guanethidine (1×10−6 M) in rat but not in porcine pulmonary arteries in which a ten-fold higher concentration significantly reduced neurogenic contractions and abolished them in 2 out of 4 tissues tested. The effect of guanethidine (1×10−6 M) observed in blood vessels of rat exceeded about five-fold that observed in porcine tissues. Thus, neurogenic responses appear to be entirely mediated by extra-junctional α1-adrenoceptors in both species, and in contrast to the rat, pig tissues seem to have a noradrenaline re-uptake that is either less efficient or operating near saturation.

Notes and References

This item contains 21 references.

  • 1.
    ['Richardson JB. Nerve supply to the lungs. Am Rev Respir Dis 1979;119:785–802.']
  • 2.
    ['Downing SE, Lee JC. Nervous control of the pulmonary circulation. Annu Rev Physiol 1980;42:199–210.']
  • 3.
    ['Wharton J, Haworth SG, Polak JM. Postnatal development of the innervation and paraganglia in the porcine pulmonary arterial bed. J Pathol 1988;154:19–27.']
  • 4.
    ['Zussman WV. Fluorescent localization of catecholamine stores in the rat lung. Anat Rec 1966;156:19–29.']
  • 5.
    ['El-Bermani AW. Pulmonary noradrenergic innervation of rat and monkey: A comparative study Thorax 1978;33:167–74.']
  • 6.
    ['McLean JR, Twarog BM, Bergofsky EH. The adrenergic innervation of pulmonary vasculature in the normal and pulmonary hypertensive rat. J Auton Nerv Syst 1985;14:111–23.']
  • 7.
    ['Costa M, Majewski H. Facilitation of noradrenaline release from sympathetic nerves through activation of ACTH receptors, beta-adrenoceptors and angiotensin II receptors. Br J Pharmacol 1988;95:993–1001.']
  • 8.
    ['Kassay-Farkas N, Wyse DG. Prevention of electrochemical oxidation of norepinephrine caused by transmural electrical stimulation. Blood Vessels 1986;23:160–4.']
  • 9.
    ['Zhong H, Minneman KP. Alpha1-adrenoceptor subtypes. Eur J Pharmacol 1999;375:261–76.']
  • 10.
    ['Bevan JA. Response of blood vessels to sympathetic nerve stimulation. Blood Vessels 1978;15:17–25.']
  • 11.
    ['Furness JB, Marshall JM. Correlation of the directly observed responses of mesenteric vessles of the rat to nerve stimulation and noradrenaline with the distribution of adrenergic nerves. J Physiol 1974;239:75–88.']
  • 12.
    ['Marshall JM. The effect of uptake by adrenergic nerve terminals on the sensitivity of arterial vessels to topically applied noradrenaline. Br J Pharmacol 1977;61:429–32.']
  • 13.
    ['Jänig W. The Integrative actions of the autonomic nervous system, Neurobiology of Homeostasis. New York: Cambridge University Press; 2006. p. 267–71.']
  • 14.
    ['Bao JX, Gonon F, Stjärne L. Frequency- and train length-dependent variation in the roles of postjunctional alpha 1- and alpha 2-adrenoceptors for the field stimulation-induced neurogenic contraction of rat tail artery. Naunyn Schmiedebergs Arch Pharmacol 1993;347:601–16.']
  • 15.
    ['Pacholczyk T, Blakely RD, Amara SG. Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter. Nature 1991;350:350–4.']
  • 16.
    ['Wyse DG. Inactivation of neural and exogenous norepinephrine in rat tail artery studied by the oil immersion technique. J Pharmacol Exp Ther 1976;198:102–11.']
  • 17.
    ['Webb RC, Vanhoute PM, Bohr DF. Inactivation of released norepinephrine in rat tail artery by neuronal uptake. J Cardiovasc Pharmacol 1980;2:121–32.']
  • 18.
    ['Stjärne L, Bao JX, Gonon F, Msghina M. Nerve activity-dependent variations in clearance of released noradrenaline: Regulatory roles for sympathetic neuromuscular transmission in rat tail artery. Neuroscience 1994;60:1021–38.']
  • 19.
    ['Bennet MR, Farnell L, Gibson WG. A quantitative description of the contraction of blood vessels following the release of noradrenaline from sympathetic varicosities. J Theor Biol 2005;234:107–22.']
  • 20.
    ['Pace JB, Cox RH, Alvarez-Vara F, Karreman G. Influence of sympathetic nerve stimulation on pulmonary hydraulic input power. Am J Physiol 1972;222:196–201.']
  • 21.
    ['Piene H. The infuence of pulmonary blood flow rate on vascular input impedance and hydraulic power in the sympathetically and noradrenaline stimulated cat lung. Acta Physiol Scand 1976;98:44–53.']