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Acridine Dyes and Other DNA-Intercalating Agents Induce the Luminescence System of Luminous Bacteria and Their Dark Variants
Shimon Ulitzur and Irith Weiser
Proceedings of the National Academy of Sciences of the United States of America
Vol. 78, No. 6, [Part 2: Biological Sciences] (Jun., 1981), pp. 3338-3342
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/10828
Page Count: 5
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Acridine dyes and other DNA-intercalating agents such as ethidium bromide, theophylline, and caffeine induce luminescence in dark variants (K variants) of different luminous species of bacteria, as well as in their wild-type luminous cells, prior to induction. The increase in luminescence appears 10-20 min after the addition of these agents and is inhibited by chloramphenicol or rifampicin. Addition of these agents affects the synthesis of both luciferase and aldehyde-synthesizing enzymes. It is hypothesized that these agents, through their intercalation into DNA, cause configurational changes resulting in derepressed transcription of the luminescence operon.
Proceedings of the National Academy of Sciences of the United States of America © 1981 National Academy of Sciences