Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If you need an accessible version of this item please contact JSTOR User Support

Leukotrienes Promote Plasma Leakage and Leukocyte Adhesion in Postcapillary Venules: In vivo Effects with Relevance to the Acute Inflammatory Response

Sven-Erik Dahlén, Jakob Björk, Per Hedqvist, Karl-E. Arfors, Sven Hammarström, Jan-Åke Lindgren and Bengt Samuelsson
Proceedings of the National Academy of Sciences of the United States of America
Vol. 78, No. 6, [Part 2: Biological Sciences] (Jun., 1981), pp. 3887-3891
Stable URL: http://www.jstor.org/stable/10943
Page Count: 5
  • Get Access
  • Read Online (Free)
  • Cite this Item
If you need an accessible version of this item please contact JSTOR User Support
Leukotrienes Promote Plasma Leakage and Leukocyte Adhesion in Postcapillary Venules: In vivo Effects with Relevance to the Acute Inflammatory Response
Preview not available

Abstract

Leukotrienes B4, C4, and D4, members of a recently discovered family of substances biosynthesized from arachidonic acid, were found to have potent microvascular actions in the hamster cheek pouch. When applied topically to the vascular network, leukotrienes C4 and D4 caused an intense constriction of arterioles, being similar to angiotensin in potency in this respect. The vasoconstriction induced by leukotrienes C4 and D4 was short-lived, and it was consistently followed by a marked and dose-dependent extravasation of macromolecules from postcapillary venules. Histamine did not constrict arterioles, but it elicited leakage of plasma, although on a molar basis it was no more than 1/1000th as potent as the leukotrienes. When used in the same concentration range as leukotrienes C4 and D4, leukotriene B4 did not evoke vasoconstriction or promote plasma leakage. On the other hand, leukotriene B4 caused a conspicuous and reversible adhesion of leukocytes to the endothelium in postcapillary venules. Our findings that leukotrienes induce microcirculatory alterations in vivo, closely resembling the early events in the acute inflammatory response, imply that leukotrienes, formed in several blood-borne and tissue-bound cells, may mediate important microcirculatory adjustments to noxious stimuli.

Page Thumbnails

  • Thumbnail: Page 
3887
    3887
  • Thumbnail: Page 
3888
    3888
  • Thumbnail: Page 
3889
    3889
  • Thumbnail: Page 
3890
    3890
  • Thumbnail: Page 
3891
    3891