You are not currently logged in.
Access JSTOR through your library or other institution:
If You Use a Screen ReaderThis content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Carbohydrate-Specified Endocytosis: Localization of Ligand in the Lysosomal Compartment
Howard B. Haimes, Richard J. Stockert, Anatol G. Morell and Alex B. Novikoff
Proceedings of the National Academy of Sciences of the United States of America
Vol. 78, No. 11, [Part 2: Biological Sciences] (Nov., 1981), pp. 6936-6939
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/11381
Page Count: 4
You can always find the topics here!Topics: Ferritins, Hepatocytes, Ligands, Kupffer cells, Molecules, Vacuoles, Receptors, Endocytosis, Liver, Coated vesicles
Were these topics helpful?See somethings inaccurate? Let us know!
Select the topics that are inaccurate.
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Preview not available
Carbohydrate-directed endocytosis is mediated by a receptor, the hepatic binding protein; it is responsible for the clearance of galactose-terminated glycoproteins from the circulation. This process was investigated by using lactosaminated ferritin which is recognized by this receptor. Ferritin was seen in elements of an extensive ``lysosomal compartment'' that includes secretory vacuoles, coated vesicles, and GERL. The compartment marked in hepatocytes by the distribution of ligand is similar to that previously described in Kupffer cells (marked by acid phosphatase reaction product and horseradish peroxidase reaction product).
Proceedings of the National Academy of Sciences of the United States of America © 1981 National Academy of Sciences