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Carbohydrate-Specified Endocytosis: Localization of Ligand in the Lysosomal Compartment

Howard B. Haimes, Richard J. Stockert, Anatol G. Morell and Alex B. Novikoff
Proceedings of the National Academy of Sciences of the United States of America
Vol. 78, No. 11, [Part 2: Biological Sciences] (Nov., 1981), pp. 6936-6939
Stable URL: http://www.jstor.org/stable/11381
Page Count: 4
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Carbohydrate-Specified Endocytosis: Localization of Ligand in the Lysosomal Compartment
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Abstract

Carbohydrate-directed endocytosis is mediated by a receptor, the hepatic binding protein; it is responsible for the clearance of galactose-terminated glycoproteins from the circulation. This process was investigated by using lactosaminated ferritin which is recognized by this receptor. Ferritin was seen in elements of an extensive ``lysosomal compartment'' that includes secretory vacuoles, coated vesicles, and GERL. The compartment marked in hepatocytes by the distribution of ligand is similar to that previously described in Kupffer cells (marked by acid phosphatase reaction product and horseradish peroxidase reaction product).

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