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The IgG Fc Receptor, FCγ RIIB, Is a Target for Deregulation by Chromosomal Translocation in Malignant Lymphoma

Mary B. Callanan, Patricia Le Baccon, Pascal Mossuz, Samuel Duley, Christian Bastard, Rifat Hamoudi, Martin J. Dyer, Gustav Klobeck, Ruth Rimokh, Jean Jacques Sotto and Dominique Leroux
Proceedings of the National Academy of Sciences of the United States of America
Vol. 97, No. 1 (Jan. 4, 2000), pp. 309-314
Stable URL: http://www.jstor.org/stable/121786
Page Count: 6
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
The IgG Fc Receptor, FCγ RIIB, Is a Target for Deregulation by Chromosomal Translocation in Malignant Lymphoma
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Abstract

Rearrangement of chromosomal bands 1q21-23 is one of the most frequent chromosomal aberrations observed in hematological malignancy. The genes affected by these rearrangements remain poorly characterized. Typically, 1q21-23 rearrangements arise during tumor evolution and accompany disease-specific chromosomal rearrangements such as t(14;18) (BCL2) and t(8;14) (MYC), where they are thus thought to play an important role in tumor progression. The pathogenetic basis of this 1q21-23-associated disease progression is currently unknown. In this setting, we surveyed our series of follicular lymphoma for evidence of recurring 1q21-23 breaks and identified three cases in which a t(14;18)(q32;q21) was accompanied by a novel balanced t(1;22)(q22;q11). Molecular cloning of the t(1;22) in a cell line (B593) derived from one of these cases and detailed fluorescent in situ hybridization mapping in the two remaining cases identified the FCGR2B gene, which encodes the immunoreceptor tyrosine-based inhibition motif-bearing IgG Fc receptor, FCγ RIIB, as the target gene of the t(1;22)(q22;q11). We demonstrate deregulation of FCGR2B leading to hyperexpression of FCγ RIIb2 as the principal consequence of the t(1;22). This is evidence that IgG Fc receptors can be targets for deregulation through chromosomal translocation in lymphoma. It suggests that dysregulation of FCGR2B may play a role in tumor progression in follicular lymphoma.

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