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The Hippocampal Neurons of Neuronal Apoptosis Inhibitory Protein 1 (NAIP1)-Deleted Mice Display Increased Vulnerability to Kainic Acid-Induced Injury
Martin Holcik, Charlie S. Thompson, Zahra Yaraghi, Charles A. Lefebvre, Alex E. MacKenzie and Robert G. Korneluk
Proceedings of the National Academy of Sciences of the United States of America
Vol. 97, No. 5 (Feb. 29, 2000), pp. 2286-2290
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/122035
Page Count: 5
You can always find the topics here!Topics: Seizures, Apoptosis, Mice, Neurons, Hippocampus, Genomics, Exons, Stem cells, Alleles, Brain damage
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The neuronal apoptosis inhibitory protein (NAIP) is a member of a novel family of inhibitor of apoptosis (IAP) proteins. The IAP genes are highly conserved from baculovirus to metazoans and suppress apoptosis induced by a variety of triggers both in vitro and in vivo. Here we describe the generation and characterization of mice with the targeted deletion of NAIP1. We demonstrate that the NAIP1-deleted mice develop normally. However, the survival of pyramidal neurons in the hippocampus after kainic acid-induced limbic seizures is greatly reduced in the NAIP1 knock-out animals. Thus, although NAIP1 is not necessary for normal development of murine central nervous system, the endogenous NAIP1 is required for neuronal survival in pathological conditions.
Proceedings of the National Academy of Sciences of the United States of America © 2000 National Academy of Sciences