You are not currently logged in.
Access your personal account or get JSTOR access through your library or other institution:
If You Use a Screen ReaderThis content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
KCNQ4, a K+ Channel Mutated in a Form of Dominant Deafness, Is Expressed in the Inner Ear and the Central Auditory Pathway
Tatjana Kharkovets, Jean-Pierre Hardelin, Saaid Safieddine, Michaela Schweizer, Aziz El-Amraoui, Christine Petit and Thomas J. Jentsch
Proceedings of the National Academy of Sciences of the United States of America
Vol. 97, No. 8 (Apr. 11, 2000), pp. 4333-4338
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/122155
Page Count: 6
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Preview not available
Mutations in the potassium channel gene KCNQ4 underlie DFNA2, an autosomal dominant form of progressive hearing loss in humans. In the mouse cochlea, the transcript has been found exclusively in the outer hair cells. By using specific antibodies, we now show that KCNQ4 is situated at the basal membrane of these sensory cells. In the vestibular organs, KCNQ4 is restricted to the type I hair cells and the afferent calyx-like nerve endings ensheathing these sensory cells. Several lines of evidence suggest that KCNQ4 underlies the IK,n and gK,L currents that have been described in the outer and type I hair cells, respectively, and that are already open at resting potentials. KCNQ4 is also expressed in neurons of many, but not all, nuclei of the central auditory pathway, and is absent from most other brain regions. It is present, e.g., in the cochlear nuclei, the nuclei of the lateral lemniscus, and the inferior colliculus. This is the first ion channel shown to be specifically expressed in a sensory pathway. Moreover, the expression pattern of KCNQ4 in the mouse auditory system raises the possibility of a central component in the DFNA2 hearing loss.
Proceedings of the National Academy of Sciences of the United States of America © 2000 National Academy of Sciences