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Multiple Differences in Gene Expression in Regulatory Vα 24Jα Q T Cells from Identical Twins Discordant for Type I Diabetes
S. Brian Wilson, Sally C. Kent, Heidi F. Horton, Andrew A. Hill, Paul L. Bollyky, David A. Hafler, Jack L. Strominger and Michael C. Byrne
Proceedings of the National Academy of Sciences of the United States of America
Vol. 97, No. 13 (Jun. 20, 2000), pp. 7411-7416
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/122827
Page Count: 6
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Quantitative and qualitative defects in CD1d-restricted T cells have been demonstrated in human and murine autoimmune diseases. To investigate the transcriptional consequences of T cell receptor activation in human Vα 24Jα Q T cell clones, DNA microarrays were used to quantitate changes in mRNA levels after anti-CD3 stimulation of clones derived from identical twins discordant for type 1 diabetes and IL-4 secretion. Activation resulted in significant modulation of 226 transcripts in the IL-4 secreting clone and 86 in the IL-4-null clone. Only 28 of these genes were in common. The differences observed suggest both ineffective differentiation of diabetic Vα 24Jα Q T cells and a role for invariant T cells in the recruitment and activation of cells from the myeloid lineage.
Proceedings of the National Academy of Sciences of the United States of America © 2000 National Academy of Sciences