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Rapid and Transient Localization of the Leader RNA of Vesicular Stomatitis Virus in the Nuclei of Infected Cells
Michael G. Kurilla, Helen Piwnica-Worms and Jack D. Keene
Proceedings of the National Academy of Sciences of the United States of America
Vol. 79, No. 17, [Part 1: Biological Sciences] (Sep. 1, 1982), pp. 5240-5244
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/12512
Page Count: 5
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The leader RNA transcript from the 3′ end of the genome of vesicular stomatitis virus (VSV) has been detected in both the nucleus and cytoplasm of infected baby hamster kidney (BHK) cells. In the cytoplasm, leader RNA accumulated gradually throughout the infection to about 200 molecules per cell at 6 hr after infection. In the nucleus, however, there was a sharp and rapid increase in the concentration of leader RNA to ≈ 300 molecules per cell at about 2 hr after infection that decreased rapidly by 3 hr. This report presents evidence for nuclear localization of transcription products of a (-)-strand RNA virus other than influenza and supports the hypothesis that the leader RNA plays a role in the shutoff of host cell transcription.
Proceedings of the National Academy of Sciences of the United States of America © 1982 National Academy of Sciences