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The Primary Ultrastructural Defect Caused by Anophthalmic White (Wh) in the Syrian Hamster

James H. Asher and Susan C. James
Proceedings of the National Academy of Sciences of the United States of America
Vol. 79, No. 14, [Part 1: Biological Sciences] (Jul. 15, 1982), pp. 4371-4375
Stable URL: http://www.jstor.org/stable/12595
Page Count: 5
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
The Primary Ultrastructural Defect Caused by Anophthalmic White (Wh) in the Syrian Hamster
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Abstract

Anophthalmic white (Wh) of the Syrian hamster is a highly pleiotropic dominant spotting color mutation causing homozygotes to be deaf, blind, and white. An ultrastructural analysis of embryonic tissue reveals that Wh causes the retention of cilia by cells of opposing layers of the embryonic retina and by the lens fiber cells. Previous ultrastructural analyses indicate that Wh also causes the retention of cilia by secretory cells of the anterior lobe of adult pituitaries. We propose that the primary ultrastructural defect caused by Wh is the retention of cilia by embryonic cells. These retained cilia are hypothesized to interfere with normal cell-cell interactions and subsequent cell differentiation.

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