Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If You Use a Screen Reader

This content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.

Dopamine Stimulation of Phosphatidylcholine (Lecithin) Biosynthesis in Rat Brain Neurons

Carol E. Leprohon, Jan K. Blusztajn and Richard J. Wurtman
Proceedings of the National Academy of Sciences of the United States of America
Vol. 80, No. 7, [Part 1: Biological Sciences] (Apr. 1, 1983), pp. 2063-2066
Stable URL: http://www.jstor.org/stable/13436
Page Count: 4
  • Read Online (Free)
  • Subscribe ($19.50)
  • Cite this Item
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Dopamine Stimulation of Phosphatidylcholine (Lecithin) Biosynthesis in Rat Brain Neurons
Preview not available

Abstract

Rat brain synaptosomes contain enzymes, phosphatidylethanolamine N-methyltransferase(s) (EC 2.1.1.17), that catalyze the methylation of endogenous phosphatidylethanolamine to form its mono-, di-, and trimethyl (i.e., phosphatidylcholine) derivatives. We observe that the activity of these enzymes is enhanced when synaptosomes are incubated with catecholamines: 0.1 mM dopamine increases incorporation of [3H]methyl groups into monomethylphosphatidylethanolamine, dimethylphosphatidylethanolamine, and phosphatidylcholine by factors of 1.7, 1.3, and 2.1, respectively, and 0.1 mM norepinephrine increases [3H]methyl incorporation into monomethyl-phosphatidylethanolamine and dimethylphosphatidylethanolamine by factors of 1.6 and 2.1, respectively. Stimulation by dopamine, which is observed at concentrations as low as 1 μ M, is blocked by haloperidol.

Page Thumbnails

  • Thumbnail: Page 
2063
    2063
  • Thumbnail: Page 
2064
    2064
  • Thumbnail: Page 
2065
    2065
  • Thumbnail: Page 
2066
    2066