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Dopamine Stimulation of Phosphatidylcholine (Lecithin) Biosynthesis in Rat Brain Neurons
Carol E. Leprohon, Jan K. Blusztajn and Richard J. Wurtman
Proceedings of the National Academy of Sciences of the United States of America
Vol. 80, No. 7, [Part 1: Biological Sciences] (Apr. 1, 1983), pp. 2063-2066
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/13436
Page Count: 4
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Rat brain synaptosomes contain enzymes, phosphatidylethanolamine N-methyltransferase(s) (EC 184.108.40.206), that catalyze the methylation of endogenous phosphatidylethanolamine to form its mono-, di-, and trimethyl (i.e., phosphatidylcholine) derivatives. We observe that the activity of these enzymes is enhanced when synaptosomes are incubated with catecholamines: 0.1 mM dopamine increases incorporation of [3H]methyl groups into monomethylphosphatidylethanolamine, dimethylphosphatidylethanolamine, and phosphatidylcholine by factors of 1.7, 1.3, and 2.1, respectively, and 0.1 mM norepinephrine increases [3H]methyl incorporation into monomethyl-phosphatidylethanolamine and dimethylphosphatidylethanolamine by factors of 1.6 and 2.1, respectively. Stimulation by dopamine, which is observed at concentrations as low as 1 μ M, is blocked by haloperidol.
Proceedings of the National Academy of Sciences of the United States of America © 1983 National Academy of Sciences