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Functional Clonal Deletion of Cytotoxic T-lymphocyte Precursors in Chimeric Thymus Produced in vitro from Embryonic Anlagen
Michael F. Good, Kenneth W. Pyke and G. J. V. Nossal
Proceedings of the National Academy of Sciences of the United States of America
Vol. 80, No. 10, [Part 1: Biological Sciences] (May 15, 1983), pp. 3045-3049
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/13710
Page Count: 5
You can always find the topics here!Topics: T lymphocytes, Chimeras, Lymphocytes, Immune tolerance, Clonal deletion, Isoantigens, Transponders, Antigens, H 2 antigens, Liver
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Chimeric thymus, formed by fusing the prelymphoid third pharyngeal pouches of fetal mice with fetal liver, have been allowed to develop entirely in vitro. Syngeneic and allogeneic chimeras were prepared and both types of thymus were shown to contain substantial numbers of functional cytotoxic T lymphocyte precursors reactive against ``third party'' alloantigens. However, alloreactivity specific for H-2 antigens present on either the third pharyngeal pouch or the fetal liver was minimal. In three different allogeneic chimeric thymuses, the frequencies of cytotoxic T lymphocyte precursors reactive to H-2 antigens present on the third pharyngeal pouches were reduced to 1%, 4%, and 0% of control values, whereas, in the one allogeneic chimera tested for alloreactivity to H-2 antigens present on the fetal liver, the cytotoxic T lymphocyte precursor frequency was reduced to less than 1% of control values. The phenotype of the H-2 tolerance is shown to be one of functional clonal deletion of the cytotoxic T lymphocyte precursor.
Proceedings of the National Academy of Sciences of the United States of America © 1983 National Academy of Sciences