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Phenomenon of Formation of Giant Fat-Containing Cells in Human Bone Marrow Cultures Induced by Human Serum Factor: Normal and Leukemic Patterns
Inna A. Svet-Moldavskaya, Svetlana N. Zinzar, George J. Svet-Moldavsky, Zalmen Arlin, Carol Vergara, Benjamin Koziner, Bayard D. Clarkson and James F. Holland
Proceedings of the National Academy of Sciences of the United States of America
Vol. 80, No. 15, [Part 1: Biological Sciences] (Aug. 1, 1983), pp. 4847-4850
Published by: National Academy of Sciences
Stable URL: http://www.jstor.org/stable/14480
Page Count: 4
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Normal human sera induce the formation of fat-containing cells (FCC) in human bone marrow cultures. A nearly complete monolayer of FCC is formed after 7-14 days of cultivation with 20% human sera in the medium. FCC-inducing activity (FCCIA) is nondialyzable through 14,000-dalton cutoff membrane and is stable at 56 degrees C for 30 min. Abundant FCCIA was found in 83% of normal human sera but in only 20% of sera from untreated patients with different hemopoietic disorders and in 32% of treated leukemic patients. It is suggested that FCCIA may be involved in regulation of the bone marrow microenvironment and that it varies in normal individuals and in patients with different diseases.
Proceedings of the National Academy of Sciences of the United States of America © 1983 National Academy of Sciences