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T-Cell Proliferation in vivo and the Role of Cytokines
Jonathan Sprent, Xiaohong Zhang, Siquan Sun and David Tough
Philosophical Transactions: Biological Sciences
Vol. 355, No. 1395, Immunological Memory (Mar. 29, 2000), pp. 317-322
Published by: Royal Society
Stable URL: http://www.jstor.org/stable/1558334
Page Count: 6
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Unlike typical naive T cells, T cells with an activated ( CD44 hi) memory phenotype show a rapid rate of proliferation in vivo. The turnover of memory-phenotype CD8+ T cells can be considerably augmented by injecting mice with various compounds, including polyinosinic-polycytidylic acid, lipopolysaccharide and immunostimulatory DNA (CpG DNA). Certain cytokines, notably type I (α, β) interferons (IFN-I), have a similar effect. These agents appear to induce proliferation of ( CD44 hi) CD8+ cells in vivo by an indirect process involving production of effector cytokines, possibly interleukin-15, by antigen-presenting cells. Although none of the agents tested induces proliferation of naive-phenotype T cells, IFN-I has the capacity to cause upregulation of surface markers on purified naive T cells. Depending upon the experimental conditions used, IFN-I can either inhibit or enhance primary responses of naive T cells to specific antigen.
Philosophical Transactions: Biological Sciences © 2000 Royal Society