You are not currently logged in.
Access JSTOR through your library or other institution:
If You Use a Screen ReaderThis content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
T-Cell Proliferation in vivo and the Role of Cytokines
Jonathan Sprent, Xiaohong Zhang, Siquan Sun and David Tough
Philosophical Transactions: Biological Sciences
Vol. 355, No. 1395, Immunological Memory (Mar. 29, 2000), pp. 317-322
Published by: Royal Society
Stable URL: http://www.jstor.org/stable/1558334
Page Count: 6
You can always find the topics here!Topics: T lymphocytes, Cytokines, Memory, Viruses, B lymphocytes, Antigens, Cell growth, Antigen presenting cells, Up regulation, Receptors
Were these topics helpful?See somethings inaccurate? Let us know!
Select the topics that are inaccurate.
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Preview not available
Unlike typical naive T cells, T cells with an activated ( CD44 hi) memory phenotype show a rapid rate of proliferation in vivo. The turnover of memory-phenotype CD8+ T cells can be considerably augmented by injecting mice with various compounds, including polyinosinic-polycytidylic acid, lipopolysaccharide and immunostimulatory DNA (CpG DNA). Certain cytokines, notably type I (α, β) interferons (IFN-I), have a similar effect. These agents appear to induce proliferation of ( CD44 hi) CD8+ cells in vivo by an indirect process involving production of effector cytokines, possibly interleukin-15, by antigen-presenting cells. Although none of the agents tested induces proliferation of naive-phenotype T cells, IFN-I has the capacity to cause upregulation of surface markers on purified naive T cells. Depending upon the experimental conditions used, IFN-I can either inhibit or enhance primary responses of naive T cells to specific antigen.
Philosophical Transactions: Biological Sciences © 2000 Royal Society