Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If You Use a Screen Reader

This content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.

Chronologic Study of the T-Virus in Chicks. I. Development of Lesions

H. W. Taylor and L. D. Olson
Avian Diseases
Vol. 17, No. 4 (Oct. - Dec., 1973), pp. 782-794
DOI: 10.2307/1589046
Stable URL: http://www.jstor.org/stable/1589046
Page Count: 13
  • Read Online (Free)
  • Download ($12.00)
  • Subscribe ($19.50)
  • Cite this Item
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Chronologic Study of the T-Virus in Chicks. I. Development of Lesions
Preview not available

Abstract

The development of the lesions associated with the T-virus in chicks was studied by microscopic examination of selected tissues at 24-hour intervals after intraperitoneal injection with macerated infected liver. On day 1 postinjection (PI), the bursa of Fabricius was smaller in the injected chicks than in the uninjected, and lympholysis occurred in the lymphoid follicles of the injected. On day 2 PI, primitive mesenchymal cells (PMC) were proliferating under the capsule of the spleen. On day 3 PI, the first PMC were observed in the liver, kidney, and lungs. On day 4 PI, the bursa contained many PMC, and PMC had obliterated the erythropoietic elements in the bone marrow. By day 5 PI, the normal architecture of the bursa and spleen had been disarranged. By day 6 PI, foci of PMC had so proliferated that they formed small macroscopic white spots on the surface of the liver, spleen, and pancreas. By day 7 PI, about 1/8 of the normal parenchyma of the liver had been replaced with PMC, and PMC were first seen in the thymus. Loss of mature lymphocytes was marked in all tissue as the disease progressed. Terminally, there was a proliferation of primitive mesenchymal cells around the blood vessels and in the centers of the lymphoid follicles. The spleen weighed significantly (P<0.05) more in injected chicks than in uninjected in the terminal stages, though the liver weighed less in injected chicks than in uninjected throughout the infection. Mortality and lesion development did not differ between bursectomized and nonbursectomized chicks.

Page Thumbnails

  • Thumbnail: Page 
782
    782
  • Thumbnail: Page 
783
    783
  • Thumbnail: Page 
784
    784
  • Thumbnail: Page 
785
    785
  • Thumbnail: Page 
786
    786
  • Thumbnail: Page 
787
    787
  • Thumbnail: Page 
788
    788
  • Thumbnail: Page 
789
    789
  • Thumbnail: Page 
790
    790
  • Thumbnail: Page 
791
    791
  • Thumbnail: Page 
792
    792
  • Thumbnail: Page 
793
    793
  • Thumbnail: Page 
794
    794