Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

If You Use a Screen Reader

This content is available through Read Online (Free) program, which relies on page scans. Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.

Indications of Immunodepression in Chickens Infected with Various Strains of Marek's Disease Virus

Ariel L. Rivas and Julius Fabricant
Avian Diseases
Vol. 32, No. 1 (Jan. - Mar., 1988), pp. 1-8
DOI: 10.2307/1590941
Stable URL: http://www.jstor.org/stable/1590941
Page Count: 8
  • Read Online (Free)
  • Download ($12.00)
  • Subscribe ($19.50)
  • Cite this Item
Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Indications of Immunodepression in Chickens Infected with Various Strains of Marek's Disease Virus
Preview not available

Abstract

The effect of infection by various strains of Marek's disease virus (MDV) on the immune function of 3-week-old chickens was examined. MDV strains of low (CU-2, RB-7) and high (RB-3, MD-5, and MD-11) pathogenicity were compared with prototype JM-10 strain of moderate pathogenicity. Mortality, whole body weight, relative weights of lymphoid organs, histopathology, humoral antibody responses to thymus-dependent and -independent antigens, and in vitro lymphocyte responses to mitogen stimulation were investigated at 1, 2, and 3 weeks postinfection. MDV strains of high pathogenicity significantly depressed responses at 3 weeks postinfection, seeming to indicate the ability of these viruses to induce severe immunodepression. However, the fact that the moderately pathogenic and even some of the low-pathogenicity strains induced immunodepression suggests that other viral mechanisms are also important in its determination. /// Se estudió el efecto de la infección sobre la función inmunológica con varias cepas del virus de la enfermedad de Marek en pollos de tres semanas de edad. Se compararon cepas de baja (CU-2, RB-7) y alta (RB-3, MD-5 y MD-11) patogenicidad con la cepa prototipo JM-10 de patogenicidad moderada. Se consideraron los siguientes parámetros a las semanas 1, 2 y 3 después de la infección: Mortalidad, peso corporal, peso relativo de los órganos linfoides, histopatología, respuesta de los anticuerpos humorales a los antígenos dependientes e independientes del timo y respuesta in vitro de los linfocitos frente a la estimulación con mitógenos. Las cepas de patogenicidad alta disminuyeron significativamente la respuesta inmunológica a las 3 semanas después de la infección indicando posiblemente la capacidad de estos virus para inducir inmunodepresión severa. Sin embargo, el hecho de que las cepas de patogenicidad moderada y algunas de patogenicidad baja indujeron inmunodepresión sugiere que otros mecanismos virales son también importantes en la determinación de inmunodepresión.

Page Thumbnails

  • Thumbnail: Page 
1
    1
  • Thumbnail: Page 
2
    2
  • Thumbnail: Page 
3
    3
  • Thumbnail: Page 
4
    4
  • Thumbnail: Page 
5
    5
  • Thumbnail: Page 
6
    6
  • Thumbnail: Page 
7
    7
  • Thumbnail: Page 
8
    8