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Effect of Dietary Selenium on the Development of Fusarium-Induced Tibial Dyschondroplasia in Broiler Chickens

Mary M. Walser, Virginia C. Morris and Orville A. Levander
Avian Diseases
Vol. 32, No. 1 (Jan. - Mar., 1988), pp. 84-88
DOI: 10.2307/1590953
Stable URL: http://www.jstor.org/stable/1590953
Page Count: 5
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Effect of Dietary Selenium on the Development of Fusarium-Induced Tibial Dyschondroplasia in Broiler Chickens
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Abstract

A trial was conducted to determine the effects of dietary level of selenium on the pathogenesis of Fusarium-induced tibial dyschondroplasia (FITD) in broiler chicks, and to assess the applicability of FITD as an animal model of Kashin-Beck disease of humans. Day-old female broilers were fed diets that were deficient in selenium (0.02 ppm Se), adequate in selenium (0.15 ppm Se), or generous in selenium (0.50 ppm Se). TDP-1, the toxic component of the fungus, was administered to 15 of 26 chicks in each dietary group starting at 1 week of age and continuing until the chicks were killed at 24-30 days of age. Plasma selenium levels and hepatic glutathione peroxidase activity were significantly lower in the selenium-deficient group than in other dietary groups; these parameters were not affected by treatment with TDP-1. The mortality rate of the TDP-1-treated selenium-generous group was significantly less than that in the other TDP-1-treated groups, but there were no differences in the incidence, severity, or character of the FITD lesions among the groups. Thus, the interaction of selenium and TDP-1 did not include an effect on FITD. /// Se realizó un experimento con el objeto de determinar los efectos de niveles de selenio en la dieta sobre la patogenesis de la discondroplasia tibial inducida por Fusarium en pollos de engorde. Así mismo, se analizó la aplicabilidad de estos resultados para desarrollar un modelo animal de estudio de la enfermedad de Kashin-Beck en humanos. Pollas de engorde de un día de edad fueron alimentadas con dietas deficientas en selenio (0.02 ppm), adecuadas (0.15 ppm) o en exceso (0.50 ppm). El selenio fue adicionado como selenita de sodio. El componente tóxico del hongo, identificado como TDP-1, fue administrado a 15 de las 26 pollas desde la primera semana hasta los 24-30 días cuando fueron sacrificadas. Los niveles de selenio en el plasma y la actividad de la glutationa peroxidasa hepática fueron significantemente menores en el grupo que recibió la dieta deficiente en selenio que en los otros grupos. Estos parámetros no se vieron afectados con el tratamiento con TDP-1. La mortalidad en el grupo con exceso de selenio en la dieta y tratado con TDP-1 fue significantemente menor que en los otros grupos tratados con TDP-1, pero no se encontraron diferencias en la incidencia, severidad o carácter de las lesiones de discondroplasia tibial inducida por Fusarium. Por lo tanto, la interacción del selenio y TDP-1 no aumentó el efecto sobre la discondroplasia tibial inducida por Fusarium.

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