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Feasibility of Using Proteins from Salmonella gallinarum vs. 9R Live Vaccine for the Prevention of Fowl Typhoid in Chickens

K. Bouzoubaa, K. V. Nagaraja, F. Z. Kabbai, J. A. Newman and B. S. Pomeroy
Avian Diseases
Vol. 33, No. 3 (Jul. - Sep., 1989), pp. 385-391
DOI: 10.2307/1591094
Stable URL: http://www.jstor.org/stable/1591094
Page Count: 7
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Feasibility of Using Proteins from Salmonella gallinarum vs. 9R Live Vaccine for the Prevention of Fowl Typhoid in Chickens
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Abstract

Proteins from a field strain of Salmonella gallinarum MSG1 were compared with 9R live vaccine strain for their protection against experimental fowl typhoid in chickens. Proteins from S. gallinarum gave better protection than the 9R live vaccine as measured by clearance of challenge organism from internal organs. Proteins given twice with an adjuvant at 200 μg/100 g body weight resulted in 95% protection, compared with 60% protection with 9R given orally. The 9R live vaccine produced more hepatic and splenic lesions and, when administered orally as a single dose, was the least protective (60%). In the group vaccinated subcutaneously with a single dose of 9R without an adjuvant, both the challenge strain and the 9R vaccine strain were isolated from the ovaries of some birds. All chickens vaccinated with 9R strain or with proteins developed antibodies detectable by microagglutination test, and in some vaccinated groups as many as 100% of the birds developed antibody levels detected by seroagglutination. /// Se compararon las proteínas de una cepa de campo de Salmonella gallinarum MSG1 con la vacuna viva cepa 9R para determinar la protección en forma experimental contra la tifoidea aviar de las aves. Las proteínas de S. gallinarum dieron mejor protección que la cepa 9R en lo relacionado a la capacidad de eliminación de los órganos internos el organismo usado en el desafío. Las proteínas administradas dos veces con un adyuvante a razón de 200 μg/100 g de peso corporal resultó en una protección del 95%, comparado con un 60% obtenido con la cepa 9R administrada por la vía oral. La vacuna 9R produjo más lesiones hepáticas y esplénicas. En el grupo vacunado por la vía subcutánea con una sóla dosis de vacuna 9R sin adyuvante, tanto la cepa de desafío como la 9R fueron aisladas de los ovarios de algunas aves. Todas las aves vacunadas con la cepa 9R o con las proteínas desarrollaron anticuerpos detectables por la prueba de microaglutinación. En algunos de los grupos vacunados, hasta el 100% de las aves desarrollaron niveles de anticuerpos detectados por seroaglutinación.

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