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In vivo Studies with Dimethyldithiocarbamate, a Possible New Antimicrobial for Use against Aspergillus fumigatus in Poultry

S. K. Delap, J. K. Skeeles, J. N. Beasley, D. L. Kreider, C. E. Whitfill, G. E. Houghten, E. M. Walker, Jr., D. J. Cannon and P. L. Earls
Avian Diseases
Vol. 33, No. 3 (Jul. - Sep., 1989), pp. 497-501
DOI: 10.2307/1591111
Stable URL: http://www.jstor.org/stable/1591111
Page Count: 5
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
In vivo Studies with Dimethyldithiocarbamate, a Possible New Antimicrobial for Use against Aspergillus fumigatus in Poultry
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Abstract

Dimethyldithiocarbamate (DmDTC), the carbamate analogue, was tested for therapeutic efficacy in a series of in vivo challenge trials using 5- and 10-week-old white leghorn chickens. Challenge organisms were Pasteurella multocida X-73, Escherichia coli O1:K1, and Aspergillus fumigatus. Birds were evaluated for survival rates, lesion scores, and the rate at which the bacteria or mold could be reisolated following challenge. Results showed DmDTC to be ineffective against P. multocida and E. coli at the treatment levels and in the form used in these trials, but DmDTC significantly reduced lesion scores and inhibited the rate of isolation of A. fumigatus compared with untreated infected birds. /// En una serie de pruebas experimentales con desafíos in vivo usando pollos tipo leghorn de 5 y 10 semanas de edad, se evaluó la eficacia terapéutica del análogo del carbamato, dimetilditiocarbamato (DmDTC). Los organismos de desafío fueron Pasteurella multocida cepa X-73, Escherichia coli cepa O1:K1, y Aspergillus fumigatus. Se evaluó la sobrevivencia de las aves, grado de las lesiones y los porcentajes de reaislamiento de las bacterias o los hongos después del desafío. Los resultados mostraron que el producto DmDTC no fue efectivo contra P. multocida o E. coli a los niveles y formas usadas en estas pruebas. Sin embargo, comparado con las aves infectadas no tratadas, el producto redujo significantemente el grado de las lesiones e inhibió el reaislamiento de A. fumigatus.

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