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Acute Toxicity of Boric Acid and Boron Tissue Residues after Chronic Exposure in Broiler Chickens

Jean E. Sander, Louise Dufour, Roger D. Wyatt, Parshall B. Bush and R. Kenny Page
Avian Diseases
Vol. 35, No. 4 (Oct. - Dec., 1991), pp. 745-749
DOI: 10.2307/1591605
Stable URL: http://www.jstor.org/stable/1591605
Page Count: 5
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Acute Toxicity of Boric Acid and Boron Tissue Residues after Chronic Exposure in Broiler Chickens
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Abstract

The acute oral mean lethal dose of boric acid in 1-day-old chickens was found to be 2.95 ± 0.35 g/kg of body weight, which classifies this product as only slightly toxic to chickens. One-day-old broiler chicks were housed in floor pens in which litter had been treated with 0, 0.9, 3.6, or 7.2 kg of boric acid per 9.9 m2 of floor space. Boron residue levels in brain, kidney, liver, and white muscle were not statistically elevated following a 15-day exposure period. Boron residue levels in the same types of tissue were not significantly elevated in chicks fed 500 ppm or 1250 ppm boric acid in feed ad libitum for 3 weeks; however, residues were significantly higher in chicks fed 2500 ppm or 5000 ppm boric acid. These data indicate that broilers grown on boric acid-treated litter do not consume enough boric acid to cause elevated boron levels in tissues. /// Se encontró que la dosis oral media letal aguda de ácido bórico en pollos de un día de edad fue de 2.95 ± 0.35 g/kg de peso corporal, clasificando este producto como ligeramente tóxico para pollos. Pollitos de engorde de 1 día edad fueron puestos en corrales cuyas camas fueron tratadas con 0, 0.9, 3.6, 7.2 kg de ácido bórico por cada 9.9 metros cuadrados de espacio. Los residuos de borón en el cerebro, riñón, hígado y músculo blanco no se aumentaron estadísticamente después de un periodo de exposición de 15 días. Los niveles residuales de borón en los mismos tipos de tejidos no se aumentaron significantemente en pollitos alimentados con 500 ppm o 1250 ppm de ácido bórico en el alimento administrado a voluntad durante 3 semanas; sin embargo, los residuos fueron significantemente más altos en los pollitos alimentados con 2500 ppm o 5000 ppm de ácido bórico. Estos datos indican que los pollos de engorde criados sobre camas tratadas con acido bórico, no consumen suficiente ácido bórico para causar un aumento de borón en los tejidos.

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