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A Highly Virulent Togavirus-Like Agent Associated with the Fulminating Disease of Guinea Fowl

Adel Brahem, N. Demarquez, M. Beyrie, A. Vuillaume and H. J. A. Fleury
Avian Diseases
Vol. 36, No. 1 (Jan. - Mar., 1992), pp. 143-148
DOI: 10.2307/1591729
Stable URL: http://www.jstor.org/stable/1591729
Page Count: 6
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
A Highly Virulent Togavirus-Like Agent Associated with the Fulminating Disease of Guinea Fowl
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Abstract

During a 1986 natural lethal outbreak of fulminating disease in guinea poult flocks in southwestern France, enveloped virus particles were consistently observed in the gut contents of infected birds. For the present study, a protocol was developed for the purification of these particles. Sucrose-banded virus obtained from birds infected experimentally with virus from the outbreak was found to have a buoyant density of 1.18 g/ml. The purified virus showed hemagglutinating activity, was shown by electron microscopy to have a togavirus-like morphology, and also was shown to be transmissible and pathogenic through oral ingestion. In addition, other enveloped particles have been occasionally detected in gut contents of both infected and uninfected birds; the improbability of the viral nature of these interfering particles is discussed. /// Durante un brote severo de una enfermedad fulminante en parvadas de gallinas de Guinea ocurrido en el suroeste de Francia, se encontraron en el contenido intestinal de las aves infectadas, partículas virales con envoltura. En este estudio se desarrolló un protocolo para la purificación de estas partículas. El virus obtenido de los animales infectados experimentalmente con virus del brote de 1986, mostró tener una densidad de 1.18 g/ml. El virus purificado mostró actividad hemoaglutinante y mediante microscopía electrónica, mostró una morfología similar al togavirus. El virus fue patógeno por la vía oral, siendo también transmitido fácilmente. Además, ocasionalmente se han detectado otras partículas con envolutra en el intestino de aves infectadas y no infectadas. Se discute la poca probabilidad de la naturaleza viral de estas partículas.

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