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Appearance of T Cells in the Bursa of Fabricius and Cecal Tonsils during the Acute Phase of Infectious Bursal Disease Virus Infection in Chickens

N. Tanimura and J. M. Sharma
Avian Diseases
Vol. 41, No. 3 (Jul. - Sep., 1997), pp. 638-645
DOI: 10.2307/1592155
Stable URL: http://www.jstor.org/stable/1592155
Page Count: 8
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Appearance of T Cells in the Bursa of Fabricius and Cecal Tonsils during the Acute Phase of Infectious Bursal Disease Virus Infection in Chickens
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Abstract

Groups of 3-wk-old specific-pathogen-free chickens were inoculated intraocularly with two virulent and one vaccine strain of infectious bursal disease virus (IBDV). During the acute phase of infection, the bursa of Fabricius and cecal tonsil were examined by immunohistochemistry for IBDV antigen and T cell. With all three viruses examined, the infection resulted in the appearance of viral antigen in the bursa accompanied by the presence of CD3+ cells. The CD3+ cells were predominantly TCR2+ and appeared at the site where viral antigens were present. The CD3+ cells continued to persist in the bursa after most of the IgM+ cells and IBDV antigen-positive cells had disappeared. Similar appearance of CD3+ cells was noted following viral antigen accumulation in the germinal centers of cecal tonsils in virulent IBDV-infected chickens. These results demonstrated that infection with IBDV resulted in extensive viral replication in the bursa and the cecal tonsils with an associated accumulation of T cells. The role these T cells may play in the pathogenesis of IBDV infection remains to be established. /// Grupos de pollos libres de patógenos específicos fueron inoculados ocularmente con dos cepas virulentas y una cepa vacunal del virus de la enfermedad infecciosa de la bolsa (Gumboro). Durante la fase aguda de la infección se examinaron por histoquímica la bolsa y las tonsilas cecales para la presencia del antígeno del virus de la enfermedad infecciosa de la bolsa y de las células T. Con todos los tres virus inoculados se observó la presencia del antígeno viral en la bolsa acompañado por la presencia de células CD3+. Las células CD3+ fueron predominantemente TCR2+ y aparecieron en el sitio en donde los antígenos virales estaban presentes. Las células CD3+ persistieron en la bolsa después de que la mayoría de células IgM+ y de que las células positivas para el antígeno habían desaparecido. Una presencia similar de células CD3+ con acumulación del antígeno viral fue observada en los centros germinales de las tonsilas cecales en pollos infectados con cepas virulentas del virus de Gumboro. Estos resultados demostraron que la infección con el virus de la enfermedad infecciosa de la bolsa produjo replicación viral extensa en la bolsa y en las tonsilas cecales asociada con una acumulación de células T. Se necesita establecer si las células T tienen un papel importante en la patogenesis de la infección por el virus de la enfermedad infecciosa de la bolsa.

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