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Development of a Chicken Model for Studying Avian Polyomavirus Infection

S. D. Fitzgerald, S. M. Williams and W. M. Reed
Avian Diseases
Vol. 40, No. 2 (Apr. - Jun., 1996), pp. 377-381
DOI: 10.2307/1592235
Stable URL: http://www.jstor.org/stable/1592235
Page Count: 5
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Development of a Chicken Model for Studying Avian Polyomavirus Infection
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Abstract

The purpose of this study was to develop a chicken model for studying the pathogenesis of avian polyomaviral infection. Ninety-two 1-day-old specific-pathogen-free (SPF) chicks were divided into the following three treatment groups: nontreated controls, treated with cyclosporine and treated with cyclophosphamide (CY). All birds were inoculated with polyomavirus; half were orally inoculated and half were inoculated by intraperitoneal (IP) injection. Spontaneous mortality and lesion development consistent with polyomaviral infection in psittacine birds occurred only in the CY-treated, IP-inoculated chicks. Immunohistochemistry confirmed that the intranuclear inclusions found microscopically were associated with polyomaviral antigen. Serology demonstrated postinoculation titers against polyomavirus in several experimental groups. One-day-old SPF chickens appear to be convenient models for investigating the pathogenesis of avian polyomavirus infection. /// El propósito de este estudio fue desarrollar un modelo en el pollo para el estudio de la patogenesis de la infección por el poliomavirus aviar. Se dividieron 92 pollitos libres de patógenos de un día de edad en tres grupos con los siguientes tratamientos: Grupo control sin tratamiento, grupo tratado con ciclosporina, y grupo tratado con ciclofosfamida. Todas las aves fueron inoculadas con el poliomavirus, la mitad por la vía oral y la mitad inyectados por la vía intraperitoneal. La mortalidad espontánea y el desarrollo de lesiones consistentes con la infección por poliomavirus en aves psitácidas ocurrió sólo en las aves inyectadas con ciclofosfamida. Por medio de la inmunohistoquímica se confirmó que las inclusiones intranucleares encontradas al microscopio estaban asociadas con el antígeno del poliomavirus. La serología mostró títulos postinoculación contra el poliomavirus en varios grupos experimentales. Los pollitos libres de patógenos de un día de edad parecen ser un modelo conveniente para investigar la patogenesis de la infección por poliomavirus aviar.

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