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Susceptibility of Pigeons to Avian Influenza

B. Panigrahy, D. A. Senne, J. C. Pedersen, A. L. Shafer and J. E. Pearson
Avian Diseases
Vol. 40, No. 3 (Jul. - Sep., 1996), pp. 600-604
DOI: 10.2307/1592270
Stable URL: http://www.jstor.org/stable/1592270
Page Count: 5
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Abstract

Susceptibility to infection with avian influenza virus (AIV) was studied in pigeons inoculated via oculonasal (Experiment 1) or intravenous (Experiment 2) route. Chickens were included as susceptible hosts in both experiments. Two subtypes each of the highly pathogenic AIV (HPAIV; HP CK/PA H5N2 and HP CK/Australia H7N7) and non-pathogenic AIV (NPAIV; NP CK/PA H5N2 and NP emu/TX H7N1) at a dose of 105 embryo infective dose per bird were used as inoculum. The pigeons inoculated with HP CK/PA H5N2 or HP CK/Australia H7N7 remained apparently healthy throughout the 21-day observation period, did not shed viruses on 3, 7, 14, and 21 days postinoculation (DPI), and had no demonstrable levels of antibodies on 21 DPI. On the other hand, 9 of 12 chickens inoculated with the HPAIV died of highly pathogenic avian influenza; the viruses were recovered from their respiratory and intestinal tissues, and the surviving chickens had antibodies to AIV. Regarding responses of pigeons to inoculation with NP CK/PA H5N2 or NP emu/TX H7N1, the pigeons remained clinically healthy throughout the 21-day observation period and did not have detectable levels of antibodies on 21 DPI; only one pigeon yielded the NP emu/TX H7N1 on 3 DPI. The virus was isolated from a tracheal swab and was believed to be the residual inoculum virus. Based on the responses of pigeons to NPAIV and HPAIV, it was concluded that the pigeons were resistant or minimally susceptible to infection with HPAIV or NPAIV. /// Se estudió la susceptibilidad de las palomas a la infección con el virus de la influenza aviar mediante la inoculación por la vía oculonasal (experimento 1) o intravenosa (experimento 2). En ambos experimentos se incluyeron pollos como huéspedes susceptibles. Como inóculo se utilizaron dos subtipos del virus de la influenza aviar, unos altamente patógenos (CK/PA H5N2 y CK/Australia H7N7) y otros no patógenos (CK/PA H5N2 y Emu/TX H7N1), a una dosis infectante para embrión de 105 por ave. Las palomas inoculadas con las cepas altamente patógenas CK/PA H5N2 o CK/Australia H7N7 permanecieron aparentemente sanas durante los 21 días del período de observación, no hubo excreción de virus a los 3, 7, 14 y 21 días post-inoculación y no tenían niveles demostrables de anticuerpos a los 21 días. Sin embargo, 9 de 12 pollos inoculados con el virus altamente patógeno de la influenza aviar murieron de la enfermedad; los virus fueron recuperados de los tejidos respiratorios e intestinal, y los pollos sobrevivientes tenían anticuerpos contra el virus de la influenza aviar. Las palomas inoculadas con los virus no patógenos CK/PA H5N2 o Emu/TX H7N1, permanecieron clínicamente sanas durante los 21 días del período de observación y no tenían niveles detectables de anticuerpos a los 21 días post-inoculación; sólo de una paloma se aisló el virus no patógeno Emu/TX H7N1 a los 3 días post-inoculación. El virus fue aislado de un hisopo traqueal y se cree que corresponde a un residuo del inóculo viral. Basados en la respuesta de las palomas a los virus no patógenos y altamente patógenos de la influenza aviar, se concluyó que las palomas fueron resistentes o ligeramente susceptibles a la infección con los virus de influenza aviar estudiados.

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