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Mutation Rate of Avian Intestinal Coliform Bacteria When Pressured with Fluoroquinolones

W. M. Medders, R. E. Wooley, P. S. Gibbs, E. B. Shotts and J. Brown
Avian Diseases
Vol. 42, No. 1 (Jan. - Mar., 1998), pp. 146-153
DOI: 10.2307/1592587
Stable URL: http://www.jstor.org/stable/1592587
Page Count: 8
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Mutation Rate of Avian Intestinal Coliform Bacteria When Pressured with Fluoroquinolones
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Abstract

The purpose of this study was to determine the rate at which resistance developed in avian coliform bacteria when exposed to nalidixic acid, sarafloxacin, or enrofloxacin. In in vitro studies, the rates of mutation of avian isolates of Escherichia coli and Salmonella were determined following nalidixic acid, sarafloxacin, or enrofloxacin pressure. The rates of mutation were similar for nalidixic acid and sarafloxacin, whereas a lower rate of mutation was seen after enrofloxacin pressure. In in vivo studies, the quinolones were administered in the drinking water to broiler chickens at a concentration of 40 ppm for five consecutive days. Samples of feces were inoculated onto appropriate media and the frequency of resistance was determined. The frequency rates of resistance to nalidixic acid and sarafloxacin were similar. Enrofloxacin-medicated birds did not develop enrofloxacin-resistant coliform bacteria. The in vitro and in vivo data appear to correlate. /// El propósito de este estudio fue determinar el nivel al cual se desarrolla resistencia en las bacterias coliformes aviares cuando son expuestas de forma continua al ácido nalidíxico, la sarafloxacina o la enrofloxacina. En estudios in vitro se determinaron los porcentajes de mutación en cepas aviares de Escherichia coli y Salmonella después de la exposición continua al ácido nalidíxico, la sarafloxacina o la enrofloxacina, el porcentaje de mutación fue similar para el ácido nalidíxico y la sarafloxacina, mientras que se obtuvo un porcentaje de mutación más bajo después de la exposición continua con la enrofloxacina. En los estudios in vivo las quinolonas fueron administradas en el agua de bebida a pollos de engorde a una concentración de 40 ppm/ml durante cinco días consecutivos. Se inocularon muestras de materia fecal en un medio apropiado y se determinó la frecuencia de resistencia. El porcentaje de frecuencia de resistencia al ácido nalidíxico y la sarafloxacina fueron similares. Las aves medicadas con enrofloxacina no desarrollaron bacterias coliformes resistentes a la enrofloxacina. La información obtenida de los estudios in vitro e in vivo parece correlacionar.

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