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Comparative Susceptibility of Selected Avian and Mammalian Species to a Hong Kong-Origin H5N1 High-Pathogenicity Avian Influenza Virus

L. E. L. Perkins and D. E. Swayne
Avian Diseases
Vol. 47, Special Issue. Proceedings of the Fifth International Symposium on Avian Influenza (2003), pp. 956-967
Stable URL: http://www.jstor.org/stable/1593374
Page Count: 12
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Comparative Susceptibility of Selected Avian and Mammalian Species to a Hong Kong-Origin H5N1 High-Pathogenicity Avian Influenza Virus
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Abstract

Seventeen avian species and two mammalian species were intranasally inoculated with the zoonotic A/chicken/Hong Kong/220/97 (chicken/HK) (H5N1) avian influenza (AI) virus in order to ascertain a relative range of susceptible hosts and the pathobiology of the resultant disease. A direct association was demonstrated between viral replication and the severity of disease, with four general gradations being observed among these species. These gradations included the following: 1) widespread dissemination with rapid and high mortality, 2) neurological disease relative to viral neurotropism, 3) asymptomatic infection or only mild transient depression associated with minor viral replication, and 4) absence of disease relative to minimal to no viral replication. This investigation not only demonstrates that the chicken/HK virus could infect multiple avian species, but also that the virulence of the chicken/HK virus varied significantly among avian species, including those species that are members of the same order. /// Se inocularon 17 especies aviares y 2 especies mamíferas con el virus zoonótico de influenza aviar A/Pollo/Hong Kong/220/97 (Pollo/HK) (H5N1) por vía intranasal con el fin de verificar el rango relativo de huéspedes susceptibles y la patobiología de la enfermedad producida. Se demostró una asociación directa entre la replicación viral y la severidad de la enfermedad con cuatro estadíos diferentes observados entre estas especies, los cuales incluyeron: 1) amplia diseminación con una mortalidad rápida y alta, 2) enfermedad neurológica relacionada con el neurotropismo viral, 3) infección asintomática o depresión pasajera suave asociada con una replicación viral menor, y 4) ausencia de enfermedad relacionada con una replicación viral mínima o ausente. Esta investigación no solamente demuestra que los virus Pollo/HK pueden infectar múltiples especies aviares sino que su virulencia varía significativamente entre las especies aviares, incluyendo aquellas especies pertenecientes al mismo orden.

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