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Heat Shock Proteins: The Fountainhead of Innate and Adaptive Immune Responses

Sreyashi Basu and Pramod K. Srivastava
Cell Stress & Chaperones
Vol. 5, No. 5 (Nov., 2000), pp. 443-451
Published by: Cell Stress Society International in partnership with Springer
Stable URL: http://www.jstor.org/stable/1601837
Page Count: 9
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Since scans are not currently available to screen readers, please contact JSTOR User Support for access. We'll provide a PDF copy for your screen reader.
Heat Shock Proteins: The Fountainhead of Innate and Adaptive Immune Responses
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Abstract

The ability of heat shock proteins to (1) chaperone peptides, including antigenic peptides; (2) interact with antigen-presenting cells through a receptor; (3) stimulate antigen-presenting cells to secrete inflammatory cytokines; and (4) mediate maturation of dendritic cells, makes them a unique starting point for generation of immune responses. These properties also permit the use of heat shock proteins for development of a new generation of prophylactic and therapeutic vaccines against cancers and infectious diseases.

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