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The Effect of Actidione on Mitosis in the Slime Mold Physarum polycephalum

J. E. Cummins, E. N. Brewer and H. P. Rusch
The Journal of Cell Biology
Vol. 27, No. 2 (Nov., 1965), pp. 337-341
Stable URL: http://www.jstor.org/stable/1604662
Page Count: 5
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The Effect of Actidione on Mitosis in the Slime Mold Physarum polycephalum
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Abstract

Actidione, reportedly a specific inhibitor of protein synthesis, was found to reduce the incorporation of labeled amino acids into proteins of the slime mold Physarum polycephalum without drastically inhibiting the incorporation of nucleic acid precursors into RNA. This inhibitor was found to completely block the ensuing mitosis if it was added at any time between telophase and late prophase. Plasmodia given Actidione in late prophase (about the time of nucleolar dissolution) went on through telophase to reconstruction even though nuclear amino acid incorporation was drastically reduced during that period.

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