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Thy-1 Is a Component Common to Multiple Populations of Synaptic Vesicles

Chung-Jiuan Jeng, Steven A. McCarroll, Thomas F. J. Martin, Erik Floor, James Adams, David Krantz, Stefan Butz, Robert Edwards and Erik S. Schweitzer
The Journal of Cell Biology
Vol. 140, No. 3 (Feb. 9, 1998), pp. 685-698
Stable URL: http://www.jstor.org/stable/1618467
Page Count: 14
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Thy-1 Is a Component Common to Multiple Populations of Synaptic Vesicles
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Abstract

Thy-1, a glycosylphosphatidylinositol-linked integral membrane protein of the immunoglobulin superfamily, is a component of both large dense-core and small clear vesicles in PC12 cells. A majority of this protein, formerly recognized only on the plasma membrane of neurons, is localized to regulated secretory vesicles. Thy-1 is also present in synaptic vesicles in rat central nervous system. Experiments on permeabilized PC12 cells demonstrate that antibodies against Thy-1 inhibit the regulated release of neurotransmitter; this inhibition appears to be independent of any effect on the Ca2+ channel. These findings suggest Thy-1 is an integral component of many types of regulated secretory vesicles, and plays an important role in the regulated vesicular release of neurotransmitter at the synapse.

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