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Neuronal Loss in Hippocampus Induced by Prolonged Ethanol Consumption in Rats

Don W. Walker, David E. Barnes, Steven F. Zornetzer, Bruce E. Hunter and Patricia Kubanis
Science
New Series, Vol. 209, No. 4457 (Aug. 8, 1980), pp. 711-713
Stable URL: http://www.jstor.org/stable/1684371
Page Count: 3
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Neuronal Loss in Hippocampus Induced by Prolonged Ethanol Consumption in Rats
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Abstract

Quantitative neurohistological techniques were used to examine the hippocampal complex of laboratory rats maintained on ethanol-containing or control diets for 5 months followed by a 2-month alcohol-free period. Chronic ethanol consumption resulted in a significant loss of hippocampal pyramidal and dentate gyrus granule cells. This study provides direct evidence that long-term ethanol consumption, in the absence of malnutrition, produces neuronal loss in the central nervous system.

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