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pH-Sensitive Liposomes: Possible Clinical Implications
M. B. Yatvin, W. Kreutz, B. A. Horwitz and M. Shinitzky
New Series, Vol. 210, No. 4475 (Dec. 12, 1980), pp. 1253-1255
Published by: American Association for the Advancement of Science
Stable URL: http://www.jstor.org/stable/1684486
Page Count: 3
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When pH-sensitive molecules are incorporated into liposomes, drugs can be specifically released from these vesicles by a change of pH in the ambient serum. Liposomes containing the pH-sensitive lipid palmitoyl homocysteine (PHC) were constructed so that the greatest pH differential (6.0 to 7.4) of drug release was obtained near physiological temperature. Such liposomes could be useful clinically if they enable drugs to be targeted to areas of the body in which pH is less than physiological, such as primary tumors and metastases or sites of inflammation and infection.
Science © 1980 American Association for the Advancement of Science