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Mutations in a Nonessential Viral Gene Permit Bacteriophage T4 to Form Plaques on Escherichia coli valS$^{\text{ts}}$relA

George L. Marchin
Science
New Series, Vol. 209, No. 4453 (Jul. 11, 1980), pp. 294-295
Stable URL: http://www.jstor.org/stable/1684935
Page Count: 2
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Abstract

During viral development bacteriophage T4 modifies the valyl-transfer RNA synthetase of its host Escherichia coli, but the function of the modification has remained elusive. A strain of Escherichia coli has now been identified which is nonpermissive for wild-type bacteriophage T4, but permissive for bacteriophage mutants impaired in the modification reaction. A comparison with other bacteria suggests that nonpermissiveness is due to synthesis of a thermolabile valyl-transfer RNA synthetase and relaxed control of RNA accumulation.

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