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Mutation Caused by Human Phagocytes

Sigmund A. Weitzman and Thomas P. Stossel
Science
New Series, Vol. 212, No. 4494 (May 1, 1981), pp. 546-547
Stable URL: http://www.jstor.org/stable/1686188
Page Count: 2
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Abstract

Histidine-requiring mutants of Salmonella typhimurium TA100 were incubated with human peripheral blood leukocytes. More of these bacteria reverted to histidine independence than controls not incubated with cells. Phagocyte-rich suspensions were mutagenic, while heat-killed cells, lymphocytes, or mixed blood leukocytes of a patient with chronic granulomatous disease were not. Production of reactive oxygen metabolites could explain the capacity of phagocytes to induce mutation.

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