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Thymosin Stimulates Secretion of Luteinizing Hormone--Releasing Factor

Robert W. Rebar, Akira Miyake, Teresa L. K. Low and Allan L. Goldstein
Science
New Series, Vol. 214, No. 4521 (Nov. 6, 1981), pp. 669-671
Stable URL: http://www.jstor.org/stable/1687215
Page Count: 3
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Thymosin Stimulates Secretion of Luteinizing Hormone--Releasing Factor
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Abstract

Partially purified thymosin fraction 5 and one of its synthetic peptide components, thymosin $\beta _{4}$, but not thymosin $\alpha _{1}$, stimulated secretion of luteinizing hormone—releasing factor from superfused medial basal hypothalami from random cycling female rats. In addition, luteinizing hormone was released from pituitary glands superfused in sequence with hypothalami. No release of luteinizing hormone in response to thymosin was observed from pituitaries superfused alone. These data provide the first evidence of a direct effect of the endocrine thymus on the hypothalamus and suggest a potentially important role for thymic peptides in reproductive function.

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