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Effect of Indomethacin on Intestinal Tumors Induced in Rats by the Acetate Derivative of Dimethylnitrosamine

Morris Pollard and Phyllis H. Luckert
Science
New Series, Vol. 214, No. 4520 (Oct. 30, 1981), pp. 558-559
Stable URL: http://www.jstor.org/stable/1687305
Page Count: 2
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Abstract

Over the course of 20 weeks, Sprague-Dawley rats developed intestinal tumors in response to an intraperitoneal injection of the acetate derivative of dimethylnitrosamine. The same agent did not induce tumors in Lobund-Wistar rats. The number of tumors was significantly smaller in rats given drinking water containing indomethacin (beginning 14 days after the injections) than in control rats given drug-free water.

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