You are not currently logged in.
Access JSTOR through your library or other institution:
Genetic Effects of the Atomic Bombs: A Reappraisal
William J. Schull, Masanori Otake and James V. Neel
New Series, Vol. 213, No. 4513 (Sep. 11, 1981), pp. 1220-1227
Published by: American Association for the Advancement of Science
Stable URL: http://www.jstor.org/stable/1687326
Page Count: 8
You can always find the topics here!Topics: Radiation dosage, Genetics, Children, Neutrons, Genetic mutation, Atomic bombs, Radiation genetics, Mortality, Statistical estimation, Sex chromosomes
Were these topics helpful?See somethings inaccurate? Let us know!
Select the topics that are inaccurate.
Preview not available
Data are presented on four indicators of genetic effects from studies of children born to survivors of the atomic bombings of Hiroshima and Nagasaki. The indicators are frequency of untoward pregnancy outcomes (stillbirth, major congenital defect, death during first postnatal week); occurrence of death in live-born children, through an average life expectancy of 17 years; frequency of children with sex chromosome aneuploidy; and frequency of children with mutation resulting in an electrophoretic variant. In no instance is there a statistically significant effect of parental exposure; but for all indicators the observed effect is in the direction suggested by the hypothesis that genetic damage resulted from the exposure. On the basis of assumptions concerning the contribution that spontaneous mutation in the preceding generation makes to the indicators in question, it is possible to estimate the genetic doubling dose for radiation for the first three indicators (the data base is still too small for the fourth). The average of these estimates is 156 rems. This is some four times higher than the results from experimental studies on the mouse with comparable radiation sources, which have been the principal guide to the presumed human sensitivities. The relevance of these data in setting permissible limits for human exposures is discussed briefly.
Science © 1981 American Association for the Advancement of Science